Greyt Inspirations Life

A little about our life, our business and our pets.

New cancer drug may help dogs, humans

The weekend was absolutely beautiful here.  The sun was shining, the temperatures were warm, the new calves were out in the field across the street.  And I had to spend this great weekend inside working on a project that was due today.  That’s the way it goes sometimes.  On the bright side, I did learn a lot about canine health which is what I was researching and writing about.



On the subject of canine health, I just read a heartbreaking message on one of my e-mail lists from a woman whose dog has recently been diagnosed with osteosarcoma in his shoulder.  The prognosis isn’t good and she was hoping someone had had some success with alternative medicine — at least more success than with chemo or surgery.


Cancer is a devastating disease in dogs, as in humans.  It is, in fact, the biggest disease killer of dogs.  I just read the figure that an estimated six million pet dogs per year are diagnosed with cancer in one form or another.


There’s an encouraging story in the news today about a breakthrough in cancer treatment.  It involves a dog but it may have applications for both dogs and humans later.  Researchers love to study tumors and cancer in dogs because cancer occurs spontaneously in dogs, just as it does in humans.  It’s not like labratory mice which are virtually bred to get cancer so they can be studied.  The DNA of dogs and humans is also closer in some ways, and so are the diseases we get, so researches can study a disease in dogs or humans and be fairly certain that their conclusions will apply to the other species.


Here’s the story about Oscar and the new cancer-fighting drug:




Oscar the Miracle Dog




‘Miracle Dog’ Beats Aggressive Cancer

Cancer-Fighting Drug Works in Dogs; Can It Do the Same for People?

By Kelli Miller Stacy

WebMD Health News

Reviewed by Louise Chang, MD

March 23, 2009 — Researchers with the Cleveland Clinic have successfully treated cancer in dogs without toxic side effects or discomfort. The feat could soon lead to a powerful new strategy for treating the disease in people.


Joseph A. Bauer, PhD, with the Center for Hematology & Oncology Molecular Therapeutics at the Cleveland Clinic, detailed the extraordinary achievement at the 237th national meeting of the American Chemical Society in Salt Lake City.


Bauer’s team’s success story begins with a “miracle dog” named Oscar, a 10-year-old male Bichon Frise stricken with an extremely aggressive form of cancer called anal sac adenocarcinoma. Chemotherapy and radiation failed to treat the dog’s disease, which left him unable to walk. Oscar had about 3 months left to live.

That’s when Bauer and colleagues gave him an innovative cancer-killing drug called nitrosylcobalamin (NO-Cbl). Within two weeks, Oscar’s cancer significantly improved and he was back on his feet.


‘Trojan Horse’ Kills Cancer

The NO-Cbl drug targets cancer cells like a biological “Trojan horse.” A Trojan horse is a damage-causing substance hidden in something apparently harmless.

In this case, the drug is made of a cancer-killing substance called nitric oxide, which is attached to vitamin B12. Substances called receptors on a cell’s surface attract the vitamin and help it enter the cell. Cancer cells grow abnormally fast with extra B12 receptors. NO-Cbl spots these receptors, sneaks into cancer cells, and releases the nitric oxide, which kills the cancer cells from within…


“We are one of the few research groups that is offering to treat dogs with cancer that otherwise have no hope,” Bauer says. “With no other options available, most people in this situation opt to euthanize so that their pets don’t go through the pain of disease and trauma of surgery.”


Bauer, a dog owner, says his research is “one of the most rewarding things I’ve ever done in my life.”



March 23, 2009 - Posted by | dogs, Pets | , , ,

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